Chordotonal organs are formed in about two hours and assembled throughout Stages 13 to 15. A cap (glial) cell then covers and connects the distal portion of the scolopale-neuron pair. We conclude that ciliated sensory neurons are not intrinsically limited in their ability to grow a new axon after proximal axon removal. Cytoplasmic walls of the cylinder then regress to leave a more prominent lymph space, within which is the cilary portion of the sensory dendrite. Moreover, each cell had at least one new neurite specified as an axon based on microtubule polarity and accumulation of the endoplasmic reticulum. Although outgrowth after proximal axotomy was variable, it depended on the core DLK axon injury signaling pathway. Here, we show that the fly voltage-gated sodium channel, Para co-localizes with the TRP channels NompC and iav and a possible dendritic spike initiation zone (SIZ) in CN dendrites. Consistent with the results of Ca 2+ imaging, chordotonal neurons of the dEaat2 mutant showed a decreased response to sound at 90 dB (Fig. However, little is known about the mechanisms by which these organs convert mechanical force into the two aforementioned senses. Most cells initiated outgrowth directly from the cell body, but neurite growth could also emerge from the short axon stump or base of the cilium. Several transient receptor potential (TRP) channels have been shown to localize to dendrites ofDrosophilamechanosensitive chordotonal neurons (CN). In Drosophila, chordotonal sensory organs mediate hearing and proprioception (the body’s awareness of motion and spatial orientation). After proximal injury, neurites regrew in a surprisingly flexible manner. These cells survived proximal axon injury as well as distal axon injury, and, like many other neurons, initiated growth from the axon stump after distal injury. NompC is also needed in the chordotonal neurons of Johnston’s organ, the Drosophila auditory system 14. We tested this hypothesis by performing laser microsurgery on ciliated lch1 neurons in Drosophila larvae and tracking cells over time. larvae can sense harsh or gentle touch with dendritic arborization (da) neurons in the body wall and can detect vibration with chordotonal organs (Cho).
We hypothesized that the lack of traditional dendrites would limit the ability of ciliated sensory neurons to respond to proximal axon injury. For example, many sensory neurons receive information from a specialized sensory cilium rather than a branched dendrite arbor. However, some neuron types do not have dendrites to be converted to a regenerating axon after proximal injury. Depending on the site of injury, new axons can grow either from the axon stump (after distal injury) or from the tip of a dendrite (after proximal injury). Axon regeneration helps maintain lifelong function of neurons in many animals.
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